The Science
Your body produces arginine. Not from food — from itself. It runs a continuous internal cycle: arginine gets converted into nitric oxide, then into citrulline, which your body recycles back into arginine. That cycle is self-generating. When it works, your blood flows, your cells get fuel, your skin and hair do what they're supposed to. When the cycle weakens — from age, stress, or genetics — everything downstream suffers. HIT formulas are built to support that cycle.
Nobel Prize in Physiology or Medicine
Three scientists won the Nobel Prize for discovering what nitric oxide does in the body.
In 1998, the Nobel Prize in Medicine went to three American scientists. They proved that the body makes nitric oxide on its own — and that it controls blood flow and cell communication throughout the body.
That discovery opened up a whole field of research. Studies since then have linked nitric oxide to skin health, hair growth, sleep, energy, and more. The science is still growing today.
What Nitric Oxide Does
After age 30, your body makes about 10% less nitric oxide every decade. By 40, most people are running well below their best level — and don't know it. Everything from your skin to your hair to your energy depends on what this molecule does.
Skin
Nitric oxide helps blood vessels relax and open up. When that happens, more blood reaches your skin. Blood carries oxygen and nutrients your skin cells need to stay healthy. Less nitric oxide means less delivery — and skin that shows it.
References: Furchgott & Zawadzki (1980); Ignarro et al. (1987)
Hair
Research shows nitric oxide plays a direct role in hair growth and pigmentation. Hair follicle cells produce it naturally. Hair grows on a 90-day cycle — and that cycle needs the right metabolic environment to complete. When the signal is weak, the cycle suffers.
References: Giordano et al., J Invest Dermatol (2003); Leclerc et al. (2025)
Energy & Metabolism
Nitric oxide helps blood vessels open so oxygen and nutrients reach your cells. When production drops, your cells get less of what they need. That shows up as slower recovery, less energy, and a body that feels like it is working harder than it should.
References: Förstermann & Sessa, Cardiovascular Research (2012)
How It Works
Here is what happens when you use the formula — step by step, in plain language.
Arginine Is Delivered
XnanodeX™ nano-particles carry arginine through the skin barrier directly to the endothelial cells that use it — bypassing the surface where most topicals stop.
Nitric Oxide Is Produced
Cells convert arginine into nitric oxide. That's the signal — the one that tells blood vessels to open up and let nutrients through.
Citrulline Is Released
Nitric oxide production leaves behind citrulline — a byproduct your body doesn't waste. It feeds back into the cycle.
The Cycle Continues
Your body converts citrulline back into arginine — regenerating the raw material for the next round of nitric oxide production. This is the arginine cycle: self-sustaining by design.
Your Cells Get What They Need
With the cycle supported, blood vessels stay open. Oxygen and nutrients reach your skin cells, hair follicles, and tissue — and they can do their jobs.
Signs of Low Nitric Oxide
Low nitric oxide does not come with a warning label. It shows up as things that seem unrelated. Most people never connect them because they have never heard of the mechanism. These are drawn from research — not a medical checklist. If any of this sounds familiar, now you know where to look.
Dullness, thinning, or loss of firmness that does not improve no matter what you try. Often tied to reduced blood flow to the skin's surface.
Research links nitric oxide directly to hair growth cycles and the process that controls hair color. When levels drop, both can be affected.
Tired even when you sleep well and eat right. Your cells need blood flow to make energy — and blood flow depends on nitric oxide.
Nitric oxide is the body's main tool for keeping blood vessels relaxed and open. When it drops, blood pressure and circulation can be affected.
Research has linked nitric oxide levels to sleep quality. Low levels may make it harder to get the deep, restful sleep your body needs.
Whether from a workout, illness, or a hard week — your body recovers by delivering nutrients to cells. That delivery depends on healthy blood flow.
Nitric oxide plays a role in how cells use energy. Research connects low levels to sluggish metabolism and reduced cellular function.
When multiple things feel off but tests come back normal, a shared upstream cause like low nitric oxide is worth understanding.
These are drawn from peer-reviewed research and provided for educational purposes only. They are not medical advice. Talk to a healthcare provider if you have health concerns.
The Delivery System
The science of nitric oxide is solid — a Nobel Prize confirms it. The hard part has always been delivery: getting arginine to the right cells so your body's own arginine cycle can do the work. XnanodeX™ was built to solve that. It delivers arginine directly through the skin to the cells that convert it — supporting a cycle your body already knows how to run.
XnanodeX™ wraps the ingredients in tiny particles small enough to pass through your skin. Most topical products sit on the surface. This one gets to the cells underneath — the ones that actually produce nitric oxide.
XnanodeX™ has shown sustained nitric oxide support with consistent use over time. It works with your body's own system — it does not add nitric oxide from outside. Your body makes it. The formula gives it what it needs to do that.
HIT formulas do not put nitric oxide into your body. They give your body the ingredients it needs to make its own. That is the right way to do it — and it is what XnanodeX™ is designed for.
All HIT formulas are made in FDA-registered facilities. No artificial fillers, colors, or preservatives. Every ingredient is chosen based on published scientific research.
Independent Research
The research behind HIT formulas is public and completely independent. These are the sources — not connected to any product.
Scientific Society
The Nitric Oxide Society
The international scientific society dedicated to the study of nitric oxide biology. Publishes the peer-reviewed journal Nitric Oxide and connects researchers studying nitric oxide's role across physiology and pathology.
British Journal of Pharmacology
Nitric Oxide: Physiology, Pathophysiology, and Pharmacology
A foundational peer-reviewed review of nitric oxide's biological roles — covering the cardiovascular system, cellular signaling, and the mechanisms by which nitric oxide production affects physiological function across body systems.
The Open Nitric Oxide Journal — Bentham Open
Open-Access Nitric Oxide Research Archive
Open-access peer-reviewed research on nitric oxide across biological systems — from vascular biology to metabolic function. Accessible to researchers and informed readers worldwide at no cost.
Halifax International Trading
Clinical References — Halifax International Trading Formulas
The peer-reviewed references that directly inform Halifax International Trading formulation approach — made available for transparency and educational purposes.
All external links open in a new tab. External organizations are entirely independent of Halifax International Trading. Their inclusion does not imply any endorsement of Halifax International Trading products.